Heparin and Calcium-Balanced Heparin

Heparin and Calcium-Balanced Heparin

As a natural glycosaminoglycan extracted and purified from mammalian tissues (such as porcine intestinal mucosa or bovine lung), heparin is one of the indispensable reagents in the fields of life science and medical research. Its core value lies in its strong and predictable anticoagulant activity. With the continuous advancement of medical technology, an increasing variety of testing methods have become available, facilitating the diagnosis and differentiation of diseases. Traditionally, biochemical tests relied on serum separation. Currently, heparin anticoagulant blood collection tubes offer the advantages of faster plasma acquisition and effectively accelerated detection, making them a relatively common method used in clinical biochemical testing.

Heparin is a mucopolysaccharide with a large molecular weight, rich in sulfate groups and multiple negative charges. It exerts excellent anticoagulant effects by inhibiting the activities of thrombin and thromboplastin in plasma, thereby achieving anticoagulation.

1.2 Calcium-Balanced Heparin: Calcium-balanced lithium heparin contains a certain amount of calcium, which pre-saturates the binding sites of heparin with ions, thereby compensating for the ions bound in the blood. This does not affect the anticoagulant effect of heparin, and also reduces its interference with test results including Ca²⁺, Na⁺, Cl⁻, pH value.

During production: Heparin + precisely proportioned Ca²⁺ + Li⁺ → form saturated calcium balanced lithium heparin.

During blood collection: Blood flows into the tube → dried heparin dissolves instantly → pre-saturated heparin no longer chelates Ca²⁺ in the sample → anticoagulates only without sequestering calcium.

2.2 Lithium Heparin: Lithium heparin shares the same anticoagulant mechanism as sodium heparin. It is mainly used for electrolyte analysis, blood gas analysis, and emergency biochemistry testing. Lithium heparin causes less interference with blood cells and ions, making it more suitable for ion concentration detection (such as potassium, sodium, calcium, etc.) and emergency test items.

Tenghu Biol specializes in the production of blood collection tube reagents and provides a variety of high-quality heparin products: Sodium Heparin (186 IU/mg), Lithium Heparin (173 IU/mg), and Calcium-Balanced Heparin (173 IU/mg). We offer a complete range of packaging specifications to meet diverse customer needs. Corresponding instructions are also provided to assist customers with solution preparation, filtration, spraying dosage, precautions, and other related issues, ensuring reliable application for our customers.