One-stop solution provider for blood collection tube manufacturing - TH Biol.
Potassium Oxalate & Sodium Fluoride
In clinical laboratory practice, the accuracy, stability and reliability of blood glucose test results are directly critical to clinical disease diagnosis, condition monitoring and the formulation of treatment regimens. Whole blood samples are highly prone to spontaneous coagulation, and glucose degradation caused by glycolysis in red blood cells, which directly leads to systematic deviations in test results. Therefore, a dedicated anticoagulation and preservation system for blood samples is indispensable.
Sodium fluoride-potassium oxalate composite reagent is a classic anticoagulant and preservative combination specially designed for blood glucose testing and verified by long-term clinical practice. It can achieve efficient anticoagulation and long-term stabilization of blood glucose simultaneously, laying a solid foundation for the accuracy of blood glucose test results starting from the sample collection stage. It is the most commonly used and best-matched standard supporting anticoagulant reagent for clinical blood glucose determination.
1. Anticoagulant Principle
Potassium Oxalate: It rapidly chelates calcium ions in plasma to form insoluble calcium oxalate precipitate, blocks the coagulation cascade reaction, and achieves rapid primary anticoagulation.
The coagulation process (intrinsic and extrinsic pathways) requires the participation of Ca²⁺ (Factor IV). Removal of Ca²⁺ → Prothrombin cannot be activated into thrombin → Fibrinogen cannot be converted into fibrin → Blood is prevented from coagulation.
Sodium Fluoride: After blood collection, red blood cells and white blood cells continuously metabolize and consume glucose through glycolysis. Sodium fluoride can specifically inhibit enolase, the key enzyme of glycolysis, block the catabolism of glucose in red blood cells, stably maintain blood glucose concentration for a long time, and prevent low biased test results.
2. Product Features
2.1 High Purity: The components are high-purity without extra interfering impurities.
2.2 Fast Dissolution: It dissolves completely and rapidly. Uniform spray coating on the tube inner wall effectively prevents nozzle blockage. Gently invert the tube after blood collection for thorough mixing, which avoids local coagulation, tube wall crystallization, hemolysis and other abnormalities. It minimizes sample rejection and improves sample qualification rate and testing efficiency.
2.3 Efficient Glycolysis Inhibition: Clinically verified, the blood glucose level of samples can remain stable for 48 hours under refrigeration at 2~8°C, and stay stable for 24 hours at room temperature. It greatly reduces the interference of delivery and testing time on results, and is suitable for emergency batch testing, external sample delivery, centralized batch testing and other application scenarios.
The binary compound formula of sodium fluoride & potassium oxalate adopts a proportion strictly in line with industry standards, serving as a dedicated supporting anticoagulant system for blood glucose and blood lactic acid testing. It ensures the specificity and accuracy of test results right from the source of sample collection. In addition, sodium fluoride features diversified compatible formulations; it can be combined with potassium oxalate, and can also be used in combination with EDTA. All testing performances fully meet the specification requirements of clinical biochemical detection.
Tenghu Biol provides high-quality blood collection tube additives, including a full range of anticoagulant and coagulant products. We offer compound formulations such as sodium fluoride + potassium oxalate and sodium fluoride + EDTA. The company can provide professional instructions for use to assist customers with the dosage and proportioning of additive solutions, ensuring the accuracy and reliability of test results.
Our main products including blood collection tube machine, serum separation gel, blood clot activator, anti-coagulant reagents, and medical consumables which are widely used in IVD diagnosis and other field.
Tel: +86 13918801906
E-mail: marketing@sh-th.com.cn
Address: No.17, Lane 5, Cao Nong Road, Songjiang District, Shanghai, China